Chunshan gui and oatp1b1

Author: goua

August undefined, 2024

WebMar 1, 2024 · OATP1B1 has broad substrate specificity and the structures of its substrates/inhibitors are quite diverse (Hagenbuch and Gui, 2008). With the increasing number of structurally diverse substrates/inhibitors for OATP1B1, it’s almost impossible to reliably superimpose hundreds of these molecules to carry out 3D-QSAR analysis. WebChunshan Gui - College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, ... polypeptides OATP1B1 and OATP1B3 are highly …

Open Access Development of a Cell-Based High-Throughput …

WebJan 1, 2024 · Chunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. WebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value. in a password

Role of transmembrane domain 10 for the function of organic …

WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more) WebJun 30, 2011 · At present, Chunshan Gui et al. have confirmed that ursolic acid was the selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010). Therefore, the drug … WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... in a pathetic manner 7 little words

The effect of herbal medicine danshensu and ursolic acid on

WebChunshan Gui, a Brett Wahlgren, a Gerald H. Lushington, b and Bruno Hagenbuch a, c, * ... Inhibition of OATP1B1-mediated estradiol-17β-glucuronide uptake by 37 nuclear … WebFeb 8, 2008 · Chunshan Gui, a Yi Miao, a Lucas Thompson, a Bret Wahlgren, a Melissa Mock, b Bruno Stieger, b and Bruno Hagenbuch a, c ... transport, we developed Chinese Hamster Ovary (CHO) cell lines stably expressing OATP1B1 or 1B3 at high levels. OATP1B1- and 1B3-mediated estradiol-17β-glucuronide uptake was inhibited by several … in a party chocolate barbieWebSep 2, 2008 · Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple. in a past era

"WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... " - Chunshan gui and oatp1b1

Chunshan gui and oatp1b1

Development of predictive QSAR models for the ... - ScienceDirect

WebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ... WebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs.

Did you know?

WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their … WebMay 29, 2014 · Chunshan Gui Authors' Affiliations: ... Transport of paclitaxel, docetaxel, and cabazitaxel was studied in vitro using various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2. Pharmacokinetic studies were done in wild-type and OATP1B2-knockout mice in the presence or absence of polysorbate 80 (PS80) …

WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their substrate drugs. 8–16 It has also been reported that many natural substances present in food or dietary supplements such as flavonoids could intact with OATP1B1 and 1B3 and … WebChunshan Gui1 and Bruno Hagenbuch1,2* 1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 ... OATP1B1. Gui and Hagenbuch PROTEIN SCIENCE VOL 18:2298—2306 2299. sulfate transport from 70% (chimera T7-12) to 32% (chimera T9-12) and 3% (chimera T11-12). …

WebApr 1, 2010 · Author links open overlay panel Chunshan Gui a, Bruno Hagenbuch a b. Show more. Add to Mendeley. Share. Cite. ... (Hagenbuch and Gui, 2008, König et al., 2006). Mice and rats have only a single transporter in the OATP1B family that is the ortholog of human OATP1B1 and OATP1B3 which arose through gene duplication after … WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride …

WebChunshan Gui a and Bruno Hagenbuch a, b Author ... nothing is known about their OATP1B1/1B3 ortholog. Therefore, we cloned and characterized the first canine organic …

WebMar 1, 2010 · Comparison of OATP1B1- and OATP1B3-mediated transport of fluorescent substrates. Uptake was measured with 1 µM of the indicated fluorescent compounds on 24-well plates for 30 min. Values are means ± SE of two combined independent experiments each performed with triplicate determinations. inaguracion basic fit gijonWebIdentification, Kidetermination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Chunshan Guia, Brett Wahlgrena, Gerald H. Lushingtonb, and Bruno Hagenbucha,c,* inah 813101chicWebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by in a password what is a characterWebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride and gliclazide, it can be deduced ... in a pat down search you are searching forWebAug 9, 2008 · Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are multispecific transporters that mediate uptake of amphipathic organic compounds into hepatocytes. The two OATPs contain 12 transmembrane domains (TMs) and share 80% amino acid sequence identity. inagural board of directorsWebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport eﬃciency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0... in a paternal way in a past life meaning