Lxr inverse agonist
WebThe basal transcriptional activity of unliganded human constitutive androstane receptor (hCAR) was shown to be repressed by the potent liver X receptor (LXR) agonist, …
Lxr inverse agonist
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WebRetinoic acid receptor (RAR)-related orphan receptors (RORs) regulate a variety of physiological processes, including hepatic gluconeogenesis, lipid metabolism, circadian rhythm and immune function.The RAR agonist: all-trans retinoic acid was reported to be an RORβ inverse agonist, but no information is available regarding ROR activity of its … WebDevelopment of Light Activated LXR Agonists ChemMedChem 10. März 2024 Veröffentlichung anzeigen. Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration ... Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1 ACS Journal of …
WebLipid efflux mechanisms, relation to disease and potential therapeutic aspects Web1 dec. 2024 · It is shown that pharmacological inhibition of LXR activity induces tumor destruction primarily through stimulation of CD8+ T-cell cytotoxic activity and …
WebReceptor modulator. A receptor modulator, or receptor ligand, is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical receptors. They are ligands that can act on different parts of receptors and regulate activity in a positive, negative, or neutral direction with varying degrees of efficacy. WebAbnormal metabolism of cholesterol may be a contributing factor in nonalcoholic steatohepatitis (NASH) pathogenesis. Accumulating evidence has shown that liver X …
WebHere we describe the anti-cancer properties of an LXR inverse agonist SR9243. Unlike previously developed targeted treatments, SR9243 selectively induces apoptosis in cancer cells but spares non-malignant tissues, exhibiting significant anti-tumor activity without overt toxicity, inflammation, or weight loss. The favorable safety profile of ...
Web(LXR) directly regulates expression of key glycolytic and lipogenic genes. To disrupt these oncogenic meta-bolism pathways, we designed an LXR inverse agonist SR9243 that … spectrum notebookWebTove Östberg is an academic researcher from Karolinska Institutet. The author has contributed to research in topic(s): Nuclear receptor & Receptor. The author has an hindex of 5, co-authored 5 publication(s) receiving 439 citation(s). spectrum not working tvWeb23 nov. 2024 · The liver X receptor (LXR) is a nuclear hormone receptor that is one of the most important regulators of cholesterol homeostasis and plays a key role in triglyceride … spectrum notes class 10 icseWeb15 mar. 2013 · Here, we describe the development of the first selective synthetic LXR inverse agonist (SR9238) and demonstrate that this compound effectively suppresses … spectrum notes upsc byjusWebGAC0003A4 is a novel LXR inverse agonist, functioning as LXR a "degrader", significantly reducing LXR protein levels in PDAC cell lines. MedKoo Biosciences, Inc. Tel: +1-919 … spectrum not working todayWebResults from the cell-based cotransfection assays demonstrate that SR9238 is a synthetic LXR inverse agonist with IC 50 s of 214 nM and 43 nM for LXRα and LXRβ, respectively. SR9238 also effectively suppresses transcription from a fatty acid synthase (Fasn) promoter driven luciferase reporter.It is found that SR9238 induces increased interaction of … spectrum nurses training bolingbrookWeb1 feb. 2015 · Liver-selective LXR inverse agonist SR9238 has been demonstrated to significantly reduce hepatic steatosis and development of NASH in obese, high-fat-diet … spectrum nursery wongawallan