Rbm3 function
WebTogether, RBM3 is a critical factor providing cellular survival advantages in an adverse microenvironment presumably by restoring translation efficacy. ... stability, function, … WebAlso, RBM3 plays an important role in neuroprotection, anti-apoptotic functions, cell proliferation as well as its function as proto-oncogene.[review] The results indicate the …
Rbm3 function
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WebJun 27, 2016 · RBM3 plays certain functions such as anti-apoptotic, cell proliferation enhancement, and a proto-oncogene function. Furthermore, Hypothermia-induced neuroprotection up- regulates RBM3 in neuronal ... WebSummary of RBM3 (IS1-RNPL) expression in human tissue. Nuclear expression in most tissues. ... Color-coding is based on tissue groups, each consisting of tissues with …
WebNX_P98179 - RBM3 - RNA-binding protein 3 - Function. Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic … WebNov 27, 2024 · Hydrogen bond, pi–pi and pi–cation are the key interactions between the RNA and the RRM domain. NMR, size exclusion chromatography and chemical cross-linking experiments show that RBM3 forms oligomers in solution, which is favoured by decrease in temperature, thus, potentially linking it to its function as a cold-shock protein.
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apopt… WebApr 11, 2024 · In our study, the RNA functional cluster of CLIP-seq suggested that RBM3 might bind to CTNNB1 (beta-catenin mRNA). Wnt/β-catenin plays an important role in bone development and the colonization of bone metastases [ 129 , 130 , 131 ], and the bone microenvironment also confers tumor cells with stemness and plastic characteristics [ …
WebNov 21, 2024 · Neural stem cells (NSCs) reside physiologically in a hypoxic niche to maintain self-renewal and multipotency. Whereas mild hypoxia is known to promote NSC proliferation, severe hypoxia in pathological conditions exerts the reverse effect. The multi-functional RNA-binding protein RBM3 is abundant in NSCs and can be regulated by hypoxic …
WebAug 4, 2024 · Several findings suggest that RBM3 has morphoregulatory functions germane to its roles in these contexts. For example, RBM3 helps maintain the morphological … lowe\u0027s riverdale utahWebFeb 2, 2024 · Given that RBM3 expression was frequently denoted in the MIBC cohort (84.8% of patients) and the finding of a reduced risk of recurrence and a prolonged survival in NAC-treated patients with high RBM3 expression, we sought to elucidate mechanisms related to RBM3 function in MIBC using an in vitro model of the well-characterized human bladder … lowe\u0027s richmond va brook roadWebRBM3 plays certain functions such as anti-apoptotic, cell proliferation enhancement, and a proto-oncogene function. Furthermore, Hypothermia-induced japanese translation for what is itWebDec 10, 2024 · The cellular functions and biological activities of RBM3 and CIRP appear to be numerous and remain largely unknown. Both RBM3 and CIRP have the capacity to bind RNA and seem to play a key role in post-transcriptional RNA modulation and translation in order to enhance global protein synthesis under stressful cellular conditions . japanese translation for shibaWebNov 27, 2024 · Hydrogen bond, pi–pi and pi–cation are the key interactions between the RNA and the RRM domain. NMR, size exclusion chromatography and chemical cross … japanese transfer pricing regulationsWebFeb 11, 2024 · Background: RNA-binding motif protein 3 (RBM3) is a cold-induced marker of good functional outcome of ischemic stroke that is promising as a protective target. … japanese translation for godWebRNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial–Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma. Purpose: RNA binding motif protein 3 (RBM3) has been reported to be dysregulated in various cancers and associated with tumor aggressiveness. Epithelial–mesenchymal transition (EMT) is an ... japanese translation for tug of war