Web- Expertise in drug design, development, and executing cost-effective, coherent, and integrated methods for drug product development to achieve organizational objectives and faster product launch. - Senior executive with a proven track record in leading Portfolio Strategy & Management and research groups. Have demonstrated the capability of … WebSolvent diversity in polymorph screening. Research output: Contribution to journal › Journal article › peer-review. Presentation; Citation formats;

J. Aaltonen

WebCrystallization from solvent is a particularly important process, as this is the primary means of purification during the intermediate and final stages of drug synthesis. Moreover, solution crystallization determines the final solid-state modification of the API namely polymorphs, solvates, and hydrates. WebImproved Pharma experts have been involved in pharmaceutical polymorph screening since the beginning. In 1995, Dr. Byrn published a paper with the FDA using decision trees to describe a strategy to identify the best solid form early in development [1]. The decision tree for polymorphs is shown in Figure 1 and was the precedent of decisions ... pop music high kiss

A practical guide to pharmaceutical polymorph screening

Webpolymorph screening; crystallization; toxicity; physicochemical descriptors; molecular interaction fields; principal component analysis (PCA) self-organizing maps (SOMs) … WebJan 21, 2008 · In polymorph screening it is imperative to maximize the physicochemical diversity of solvents used in crystallization experiments. This is done in order to increase … share vigilance